HCID 68003822, compound → HCID 68003854, compound

HRID 1896821Notes

Reaction equation

HRID 1896821 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH:11]3[NH:15][C:14](=[O:16])[CH:13]=[CH:12]3)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1>[Pd].CO>[O:1]1[C:5]2([CH2:6][CH2:7][CH:8]([CH:11]3[NH:15][C:14](=[O:16])[CH2:13][CH2:12]3)[CH2:9][CH2:10]2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 68003822HCID 68003822, compound

Product 1

HCID 68003854HCID 68003854, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a mixture of 5-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrrol-2(5H)-one (330 mg, 1.48 mmol), prepared in the previous step, and Palladium on Carbon (299 mg, 0.14 mmol, 5%, “Degussa, wet”) was carefully added methanol (30 mL). The reaction flask was evacuated, backfilled with hydrogen via balloon and stirred at room temperature overnight. The catalyst was removed by filtration and the filtrate concentrated in vacuo to afford the product.

Workup

  1. customThe reaction flask was evacuated
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate concentrated in vacuo
  4. customto afford the product

Sources & evidence

ORD record
ord-e3c2a2c0a0d2432ca28c3495a3292c60
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

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