反应详情

To a mixture of 5-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrrol-2(5H)-one (330 mg, 1.48 mmol), prepared in the previous step, and Palladium on Carbon (299 mg, 0.14 mmol, 5%, “Degussa, wet”) was carefully added methanol (30 mL). The reaction flask was evacuated, backfilled with hydrogen via balloon and stirred at room temperature overnight. The catalyst was removed by filtration and the filtrate concentrated in vacuo to afford the product.

1. customThe reaction flask was evacuated
2. customThe catalyst was removed by filtration
3. concentrationthe filtrate concentrated in vacuo
4. customto afford the product