Tetrabutylammonium Fluoride → HCID 58562670, compound

Participants

Reaction Steps

To a solution of trimethyl (2,2,3,3,4,4,4-heptafluoro-1-(1,4-dioxaspiro[4.5]decan-8-yl)butoxy)trimethylsilane (265 mg, 0.643 mmol, prepared in the previous step) in THF (10 mL) was added a TBAF (0.64 mL, 0.64 mmol, 1 M in THF) dropwise. After the complete addition, the reaction mixture was at room temperature 2 hours and then concentrated in vacuo. The residue purified by flash chromatography (silica gel, 0-100% ethyl acetate/heptane) to afford the product.

Provenance & Evidence