HCID 58562577, compound → HCID 58562870, compound

HRID 1896853Notes

Reaction equation

HRID 1896853 reaction equation
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[CH2:16][CH2:15][C:10]3([O:14][CH2:13][CH2:12][O:11]3)[CH2:9][CH:8]=2)[CH2:3][CH2:2]1>[Pd].CO>[O:1]1[CH2:2][CH2:3][CH:4]([CH:7]2[CH2:16][CH2:15][C:10]3([O:11][CH2:12][CH2:13][O:14]3)[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 58562577HCID 58562577, compound

Product 1

HCID 58562870HCID 58562870, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a flask containing 8-(3,6-dihydro-2H-pyran-4-yl)-1,4-dioxaspiro[4.5]dec-7-ene (218 mg, 0.972 mmol), prepared in the Example 28 Step B, and Palladium on Carbon (157 mg, 0.074 mmol) was carefully added methanol (24 mL). The reaction flask was evacuated, backfilled with hydrogen via balloon and stirred at room temperature overnight. The catalyst was removed by filtration and the filtrate concentrated in vacuo to afford the product.

Workup

  1. customThe reaction flask was evacuated
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate concentrated in vacuo
  4. customto afford the product

Sources & evidence

ORD record
ord-6d414af31dbf429681be77bc632d196e
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

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