HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1896872Generated: October 30, 2026
Succinimide → 1-(1,4-Dioxaspiro[4.5]decan-8-yl)pyrrolidine-2,5-dione
https://huagongshe.com/reaction/1896872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Succinimide | HCID 11439 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-pyridin-3-ol | HCID 58562515 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(1,4-Dioxaspiro[4.5]decan-8-yl)pyrrolidine-2,5-dione | HCID 58562710 | — |
Reaction Steps
A solution of pyrrolidine-2,5-dione (210 mg, 2 mmol) in DMF was treated with sodiumhexamethyldisilazid (1.5 eq), stirred for 30 min and treated with 4-dioxaspiro[4.5]decan-8-yl methanesulfonate (250 mg, 1 mmol) from example 1, step A, and heated at 80° C. for 18 h. DMF was removed under vacuum and the residue was purified by silica column chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08518969B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-179cad7f78bf482fa1986215754e7b14 |
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| Source note | uspto-grants-2013_08 |
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