反应详情

A methanolic solution of ethyl 4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)quinoline-2-carboxylate (53 g, 131 mmol) from above step A, was cooled in an ice bath and saturated with ammonia by bubbling in ammonia. The flask was capped and stirred at room temp for 20 h. The white precipitate that formed was collected by filtration and washed with a small amount of MeOH and dried under vacuum to give the title compound.

1. customby bubbling in ammonia
2. customThe flask was capped
3. customThe white precipitate that formed
4. filtrationwas collected by filtration
5. washwashed with a small amount of MeOH
6. customdried under vacuum