HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 1-Chloro-7-(trifluoromethyl)isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-Methoxy-7-(trifluoromethyl)isoquinoline | HCID 58562521 | — |
| Product | 1-Chloro-7-(trifluoromethyl)isoquinoline | HCID 58562677 | — |
Reaction Steps
A solution of 1-Methoxy-7-(trifluoromethyl)isoquinoline (50 mg, 0.22 mmol) from above step B in phosphorus oxychloride (1 mL) was heated at 150° C. for 18 h. Phosphorus oxychloride was removed under vacuum and the residue was purified by silica column chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518969B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-49f334421ef24f0980dc713439ba59bc |
| Source note | uspto-grants-2013_08 |