反应详情

To a flask containing tert-butyl 3-(2-(((benzyloxy)carbonyl)(methyl)amino)acetamido)azetidine-1-carboxylate (3.10 g, 8.21 mmol, prepared in the previous step) and a stirbar, was added 10% Pd/C (136 g, 0.127 mmol). The flask was evacuated and back filled with argon. Methanol (100 mL) was carefully added via syringe and the flask was evacuated with stirring. It was then back filled with hydrogen and stirred 2 days under a hydrogen balloon. After evacuation with stirring and back filling with argon, the catalyst was removed by filtration over Celite 521 and concentrated in vacuo to afford the product.

1. customprepared in the previous step) and a stirbar
2. customThe flask was evacuated
3. additionback filled with argon
4. additionMethanol (100 mL) was carefully added via syringe
5. customthe flask was evacuated
6. additionIt was then back filled with hydrogen
7. stirringstirred 2 days under a hydrogen balloon
8. stirringAfter evacuation with stirring
9. customthe catalyst was removed by filtration over Celite 521
10. concentrationconcentrated in vacuo
11. customto afford the product