HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-ene → HCID 54772206, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-ene | HCID 3697076 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 4-Bromo-3-methoxypyridine | HCID 13793629 | — |
| Reactant | HCID 68003374 | HCID 68003374 | — |
| Reactant | N-(azetidin-3-yl)-2((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide | HCID 68003594 | — |
| Product | HCID 54772206 | HCID 54772206 | — |
Reaction Steps
Reaction of 4-(3-methoxypyridin-4-yl)cyclohexanone (prepared by the reaction of 4-bromo-3-methoxypyridine with 8-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,4-dioxa-spiro[4.5]dec-7-ene using the sequence described in Example 1 Step A-C) with N-(azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide (as prepared in Example 1 Step G) in the presence of TEA and NaBH(OAc)3 as described in Example 1, Step H afforded the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518969B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-5466d88c4baf4dc3b213f72bd053e46b |
| Source note | uspto-grants-2013_08 |