(S)-3-(3-nitro-1h-pyrazol-1-yl)propane-1,2-diol → (S)-3-(3-Amino-1H-pyrazol-1-YL)propane-1,2-diol

Participants

Reaction Steps

In a Parr shaker bottle was placed (S)-3-(3-nitro-pyrazol-1-yl)-propane-1,2-diol (2.28 g, 12.19 mmol), 10% palladium on activated carbon (200 mg) and ethanol (30 mL). The bottle was then placed on the Parr shaker at 50 psi of hydrogen pressure for 5 h. The reaction was then filtered through a pad of celite and washed with ethanol and concentrated in vacuo to afford (S)-3-(3-amino-pyrazol-1-yl)-propane-1,2-diol (1.69 g, 88%) as a yellow oil: LR-ES-MS m/z calculated for C6H11N3O2 [M]+ 157, observed [M+H]+ 158.

Provenance & Evidence