Hydrochloric Acid → 1-1,4-Dioxaspiro[4.5]decan-8-ylpropan-1-amine hydrochloride

Participants

Reaction Steps

To a solution of N-(1-(1,4-dioxaspiro[4.5]decan-8-yl)propyl)-2-methylpropane-2-sulfinamide (as prepared in the previous step, 2.55 g, 8.39 mmol) in dry MeOH (50 mL) was added HCl (14 mL, 17.5 mmol, 1.25 M in MeOH) at room temperature. After stirring overnight at ambient temperature, the reaction mixture was concentrated in vacuo. Trituration of the residue with ether, followed by decantation of the supernatant and drying the residue under high vacuum afforded the product as a white foam.

Provenance & Evidence