反应详情

温度

70 °C

Into a 50 mL round-bottom flask were placed a solution of 1-1,4-dioxaspiro[4.5]decan-8-ylpropan-1-amine hydrochloride (as prepared in Example 104 Step B) (100 mg, 0.42 mmol, 1.00 equiv) in water (3 mL) and KOCN (38 mg, 0.47 mmol, 1.10 equiv). The resulting solution was stirred overnight at 70° C. The resulting solution was cooled and extracted with 3×10 mL of dichloromethane. The organic layers were combined, dried and concentrated under vacuum to give the title compound as a white solid.

1. customInto a 50 mL round-bottom flask were placed
2. temperatureThe resulting solution was cooled
3. extractionextracted with 3×10 mL of dichloromethane
4. customdried
5. concentrationconcentrated under vacuum