HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1896965Generated: October 30, 2026
Phosphorus pentachloride → 2-(4-Chloro-phenylsulfonylamino)4,5-dimethoxy-benzoyl chloride
https://huagongshe.com/reaction/1896965
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 2-{[(4-Chlorophenyl)sulfonyl]amino}-4,5-dimethoxybenzoic acid | HCID 1239991 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Chloro-phenylsulfonylamino)4,5-dimethoxy-benzoyl chloride | HCID 9843367 | 93% |
Reaction Steps
25.90 g (0.07 mol) of 2-(4-chloro-phenylsulfonylamino)-4,5-dimethoxy-benzoic acid were mixed with 75 ml of toluene, 17.30 g (0.08 mol) of phosphorus pentachloride were added and the mixture was stirred at 40-45° C. for 2.5 h. Then the mixture was concentrated in vacuo to half of its volume and the product that precipitated was filtered off with suction and washed with a small amount of toluene. 25.30 g (93%) of 2-(4-chloro-phenylsulfonylamino)-4,5-dimethoxy-benzoyl chloride having a melting point of 175-177° C. were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08518998B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-c5e542d974ec4b5592f569bb375497bc |
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| Source note | uspto-grants-2013_08 |
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