HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1896970Generated: October 31, 2026
4-Toluenesulfonyl chloride → (S)-2-(2,2,4-trimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzene sulfonate
https://huagongshe.com/reaction/1896970
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol | HCID 11062680 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-2-(2,2,4-trimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzene sulfonate | HCID 13343712 | — |
Reaction Steps
To a solution of compound 4 and Et3N in DCM was added TsCl dropwise. The resulting mixture was stirred at 0° C. for 30 min. The solid was filtered and the solvent was removed. The residue was purified by column chromatography to give compound 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08518984B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-651cd834aaa743a59b8f4dea8aa7a928 |
|---|
| Source note | uspto-grants-2013_08 |
|---|
