反应详情

A 3.5 g sample of the alcohol from step 471a above was dissolved in 25 mL of methylene chloride and treated with methanesulfonyl chloride an TEA at 0° C. for 2 hours. The reaction mixture was washed with NaHCO3 solution and water, and the solvent was removed. The residue was chromatographed on silica gel to give 3 g of the title compound.

1. washThe reaction mixture was washed with NaHCO3 solution and water
2. customthe solvent was removed
3. customThe residue was chromatographed on silica gel