Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate → (3-(4-Chlorophenyl)-5-methylisoxazol-4-yl)methanol

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Reaction Steps

As described for example 88d, 3-(4-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (373 mg, 1.4 mmol) was converted, instead of 3-(3-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (204 mg, 65%) which was obtained as a white solid. MS: m/e=224.1 [M+H]+.

Provenance & Evidence