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4-Aminotetrahydropyran → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminotetrahydropyran | HCID 419223 | — |
| 反応物 | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68445257 | — |
| 生成物 | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide | HCID 68442702 | 99% |
反応手順
As described for example 162b, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (70 mg, 0.24 mmol) was converted using 4-aminotetrahydropyran instead of ethanolamine to the title compound (SiO2, heptane:ethyl acetate=50:50 to 0:100, 89 mg, 99%) which was obtained as a white solid. MS: m/e=381.5 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08518974B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-48e53caad78a4d6f8d985859c31c7fe1 |
| 出典メモ | uspto-grants-2013_08 |