Formaldehyde → HCID 62278273, compound

HRID 1897372Notes

Reaction equation

HRID 1897372 reaction equation
[CH2:1]=O.[CH:3](=[O:7])[CH:4]([CH3:6])[CH3:5].[CH2:8]([NH:15][CH:16]([CH3:18])[CH3:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH3:5][C:4]([CH3:1])([CH2:6][N:15]([CH:16]([CH3:18])[CH3:17])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:3]=[O:7]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 6561IsobutyraldehydeHCID 66024Isopropylbenzylamine

Product 1

HCID 62278273HCID 62278273, compound

Procedure

Under the same conditions as for the preparation of 2,2-dimethyl-3-(N-morpholino)propanal, 28.0 g (0.34 mol) of 36% aqueous formaldehyde were reacted with 25.4 g (0.35 mol) of isobutyraldehyde and 50.0 g (0.34 mol) of N-benzylisopropylamine, and worked up. The product distilled at a top temperature of 100° C. and a pressure of 4·10−2 mbar. Yield: 48.6 g (62% of theory) as a pale yellow, clear and almost odorless liquid which had an amine content of 4.28 mmol N/g.

Workup

  1. distillationThe product distilled at a top temperature of 100° C.

Sources & evidence

ORD record
ord-c716eefdecb9403da2042d8db488310a
Source dataset
uspto-grants-2013_08
Patent number
US08519038B2

Reaction notes

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