HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonamide, 3-amino- → HCID 25263013, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonamide, 3-amino- | HCID 7377 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 6-tert-Butylpyridine-3-carboxylic acid | HCID 21897804 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25263013 | HCID 25263013 | — |
Reaction Steps
A solution of 6-tert-butylpyridine-3-carboxylic acid (18 mg, 0.10 mmol) and HATU (38 mg, 0.10 mmol) in DMF (1 mL) was stirred at room temperature for 3 minutes. To this solution was added 3-amino-benzenesulfonamide (17 mg, 0. 10 mmol) and triethylamine (28 μL, 0.20 mmol). The reaction was stirred at room temperature for 16 h and purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give 6-tert-butyl-N-(3-(aminosulfonyl)phenyl)pyridine-3-carboxamide. LC/MS: m/z 334.3 (M+H)+ at 1.99 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519137B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-18ef41e7e2434bc1ad5f667a498a4402 |
| Source note | uspto-grants-2013_08 |