HCID 69937938, compound → HCID 71087651, compound

Participants

Reaction Conditions

Reaction Steps

To 13a (3.44 g, 13.09 mmol) in toluene (13.09 ml) at room temperature was added amberlyst 15 (700 mg, 13.09 mmol). The mixture was stirred at 200° C. for 10 min in microwave. The mixture was cooled to room temperature and then the solvent was concentrated. The residue was purified via Biotage (heptane; SNAP25 column) giving 13b (505 mg, 23%) as a colorless oil. 1H NMR of major isomer in mixture (400 MHz, MeOD) δ ppm 6.84 (dd, J=2.27, 0.95 Hz, 1H) 7.46 (dd, J=9.16, 0.95 Hz, 1H) 7.71 (d, J=7.39 Hz, 1H) 7.81 (d, J=2.27 Hz, 1H).

Provenance & Evidence