4-(Diethoxymethyl)benzaldehyde → 1-[4-(diethoxymethyl)phenyl]-N-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]methanamine
Reaction equation
[CH2:1]([O:3][CH:4]([O:13][CH2:14][CH3:15])[C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)[CH3:2].[CH3:16][Si:17]([CH3:30])([CH3:29])[CH2:18][CH2:19][O:20][CH2:21][N:22]1[CH:26]=[CH:25][N:24]=[C:23]1[CH2:27][NH2:28]>>[CH2:1]([O:3][CH:4]([O:13][CH2:14][CH3:15])[C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:28][CH2:27][C:23]2[N:22]([CH2:21][O:20][CH2:19][CH2:18][Si:17]([CH3:30])([CH3:29])[CH3:16])[CH:26]=[CH:25][N:24]=2)=[CH:7][CH:6]=1)[CH3:2]Participants
3
Procedure
With 4-(diethoxymethy)benzaldehyde (957 mg) and 1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methanamine (1.05 g), the same operation as in Example 2 was performed to obtain the title compound (2.05 g) having the following physical properties.
Sources & evidence
- ORD record
- ord-2386a57a066f49aa99f18fd6e3e876ba
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08519124B2
Reaction notes
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