HRID1897638

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10997953

Cyclohexanone, 4-(dipropylamino)-

C12H23NO

结构：CN(C)S(=O)(=O)n1ccnc1CN(Cc1nccn1S(=O)(=O)N(C)C)C(=O)c1ccc2c(c1)CCNC2

HCID67500558

未命名化合物

PRODUCTS

生成物

结构：CCCN(CCC)C1CCC(N2CCc3cc(C(=O)N(Cc4nccn4S(=O)(=O)N(C)C)Cc4nccn4S(=O)(=O)N(C)C)ccc3C2)CC1

HCID67502292

未命名化合物

收率 75.2%

PROCEDURE

实验过程

The same operation as in Example 2 was performed, except for using the compound (150 mg) obtained in Example 31 and 4-(dipropylamino)cyclohexanone (269 mg), and then the obtained crude product was purified by silica gel chromatography (dichrolomethane:methanol:28% aqueous ammonia=1:0:0→80:10:1) to obtain the title compound (150 mg) having the following physical properties.

WORKUP

后处理

customthe obtained crude product
customwas purified by silica gel chromatography (dichrolomethane:methanol:28% aqueous ammonia=1:0:0→80:10:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-46cd997360f847a99956c416559476f1
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08519124B2
来源说明: uspto-grants-2013_08

反应 SMILES

[CH3:1][N:2]([CH3:37])[S:3]([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][N:12]([CH2:25][C:26]1[N:27]([S:31]([N:34]([CH3:36])[CH3:35])(=[O:33])=[O:32])[CH:28]=[CH:29][N:30]=1)[C:13]([C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH2:21][NH:20][CH2:19][CH2:18]2)=[O:14])(=[O:5])=[O:4].[CH2:38]([N:41]([CH2:49][CH2:50][CH3:51])[CH:42]1[CH2:47][CH2:46][C:45](=O)[CH2:44][CH2:43]1)[CH2:39][CH3:40]>>[CH3:35][N:34]([CH3:36])[S:31]([N:27]1[CH:28]=[CH:29][N:30]=[C:26]1[CH2:25][N:12]([CH2:11][C:7]1[N:6]([S:3]([N:2]([CH3:37])[CH3:1])(=[O:4])=[O:5])[CH:10]=[CH:9][N:8]=1)[C:13]([C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH2:21][N:20]([CH:45]1[CH2:46][CH2:47][CH:42]([N:41]([CH2:49][CH2:50][CH3:51])[CH2:38][CH2:39][CH3:40])[CH2:43][CH2:44]1)[CH2:19][CH2:18]2)=[O:14])(=[O:33])=[O:32]