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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1897667Generated: October 30, 2026

1-Bromo-2,5-dimethyl-4-nitrobenzene → tert-Butyl 3-(2,5-dimethyl-4-nitrophenyl)azetidine-1-carboxylate

https://huagongshe.com/reaction/1897667

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2,5-dimethyl-4-nitrobenzeneHCID 825808—
ReactantTert-butyl 3-iodoazetidine-1-carboxylateHCID 11000522—
Producttert-Butyl 3-(2,5-dimethyl-4-nitrophenyl)azetidine-1-carboxylateHCID 86653270—

Reaction Steps

Prepared from tert-butyl 3-iodoazetidine-1-carboxylate and 1-bromo-2,5-dimethyl-4-nitrobenzene by following the general protocol as described in Billotte, S. Synlett 1998, 379.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08519129B2
Source datasetuspto-grants-2013_08
ORD IDord-1b06506bef954678802033cf343ef154
Source noteuspto-grants-2013_08