4-Ethylbenzene-1-sulfonyl chloride → N-[5-(3-chloro-4-cyano-phenyl)-pyridin-3-yl]-4-ethyl-benzenesulfonamide

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Reaction Steps

According to General Sulfonylation Procedure 2 in example 1, to a solution of 4-(5-amino-pyridin-3-yl)-2-chloro-benzonitrile (20 mg, 87 μmol, 1 eq) in anhydrous pyridine (500 μl) was added 4-ethyl-benzenesulfonyl chloride (15.5 μl, 96 μmol, 1.1 eq). The product was purified by precipitation in methanol and lyophilized to give N-[5-(3-chloro-4-cyano-phenyl)-pyridin-3-yl]-4-ethyl-benzenesulfonamide (14.3 mg, >95% purity, yield: 41.4%).

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