HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenoxyethane-1-sulfonyl chloride → N-(5-(3-chloro-4-cyanophenyl)pyridin-3-yl)-2-phenoxyethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenoxyethane-1-sulfonyl chloride | HCID 6486628 | — |
| Reactant | 4-(5-Amino-pyridin-3-yl)-2-chloro-benzonitrile | HCID 59578390 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(5-(3-chloro-4-cyanophenyl)pyridin-3-yl)-2-phenoxyethanesulfonamide | HCID 49819666 | 22.5% |
Reaction Steps
According to General Sulfonylation Procedure 2 in Example 1, to a solution of 4-(5-amino-pyridin-3-yl)-2-chloro-benzonitrile (20 mg, 87 μmol, leg) in anhydrous pyridine (500 μl) was added 2-phenoxy-ethanesulfonyl chloride (21.14 mg, 96 μmol, 1.1 eq). The product was purified by preparative TLC, the plate was eluted with dichloromethane/methanol 95/5, to give N-(5-(3-chloro-4-cyanophenyl)pyridin-3-yl)-2-phenoxyethanesulfonamide (8.1 mg, >95% purity, yield: 22.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519142B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-ed0afd499da94bfa8ae8e38eabc2d337 |
| Source note | uspto-grants-2013_08 |