Trifluoroacetic acid → HCID 58399742, compound

Participants

Reaction Steps

To the resulting tert-butyl 2-[4-(3,4-bis(tert-butoxycarbonylamino)thien-2-yl)phenyl]-4-tert-butoxycarbonylaminothien-3-ylcarbamate was added 80 equivalents of trifluoroacetic acid, and a reaction was performed at 25° C. for 3 hours. The resulting reaction liquid was dropped slowly to a saturated aqueous sodium carbonate solution to neutralize, thereby stopping the reaction. Ethyl acetate was added to the reaction liquid and stirred, and then the organic layer was taken and the solvent was distilled off, and the residue was purified by silica gel column chromatography using an ethyl acetate/hexane solvent, so that 2-[4-(3,4-diaminothien-2-yl)phenyl]thiophene-3,4-diamine was obtained. The yield based on the charged tert-butyl 2-[4-(3,4-bis(tert-butoxycarbonylamino)thien-2-yl)phenyl]-4-tert-butoxycarbonylaminothien-3-ylcarbamate was 90%.

Provenance & Evidence