Urea → HCID 46899385, compound

Participants

Reaction Conditions

Reaction Steps

To the resulting 2-[4-(3,4-diaminothien-2-yl)phenyl]thiophene-3,4-diamine were added 2.2 equivalents of urea and amyl alcohol in an amount equivalent to 10 ml/mmol, and under argon gas atmosphere, a reaction was advanced by refluxing at 130° C. for 5 hours, then amyl alcohol was distilled off and the residue was purified by silica gel column chromatography using an ethyl acetate/hexane solvent, so that 4-[4-(2,3-dihydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)phenyl]-2,3-dihydro-1H-thieno[3,4-d]imidazol-2-one was obtained. The yield based on 2-[4-(3,4-diaminothien-2-yl)phenyl]thiophene-3,4-diamine was 60%.

Provenance & Evidence