HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → (3S,4S,6R)-6-benzhydryl-4-benzylamino-tetrahydropyran-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | (1S,4R,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane | HCID 86605348 | — |
| Product | (3S,4S,6R)-6-benzhydryl-4-benzylamino-tetrahydropyran-3-ol | HCID 66632020 | — |
Reaction Steps
(1S,4R,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]heptane 28d (0.019 g, 0.071 mmol) was reacted with benzylamine (0.15 g, 1.43 mmol) (Procedure E) to yield (3S,4S,6R)-6-benzhydryl-4-benzylamino-tetrahydropyran-3-ol, (+)-29h, 0.023 (85%, [α]D=(+)70.1, c=1, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519159B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-c33ef3a1b23b42c3bb1de1624ed14733 |
| Source note | uspto-grants-2013_08 |