Water → HCID 178428256, compound

Participants

Reaction Conditions

Reaction Steps

24.9 mg of 2-((1-(3-chloro-2-fluorobenzoyl)piperidin-4-yl)methyl)-6-methyl-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)pyrimidin-4-amine was dissolved in 0.9 ml of trifluoroacetic acid and 0.1 ml of water at room temperature, followed by stirring the reaction mixture at 60° C. for 30 minutes. The reaction mixture was cooled to room temperature, and concentrated in vacuo. The reaction mixture was purified by a reversed phase preparative liquid chromatography, followed by concentrating the obtained fraction in vacuo to give the title compound as a white solid.

Provenance & Evidence