1,1'-Carbonyldiimidazole → HCID 58097144, compound

Participants

Reaction Steps

To a solution of 68.5 mg of 4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-1-(2-fluoro-3-(trifluoromethyl)benzoyl)piperidine-4-carbohydrazide in 5 ml of tetrahydrofuran was added 23.7 mg of 1,1′-carbonyldiimidazole at room temperature. The reaction mixture was stirred at room temperature overnight, and concentrated in vacuo. The resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate=20/1 to ethyl acetate) to give the title compound as a colorless oil.

Provenance & Evidence