3-(Trifluoromethyl)aniline → HCID 44621464, compound

HRID 1897966Notes

Reaction equation

HRID 1897966 reaction equation
[CH:1]1([CH:7]=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:9][C:10]([F:19])([F:18])[C:11]1[CH:12]=[C:13]([NH2:17])[CH:14]=[CH:15][CH:16]=1.[C:20]([OH:24])(=O)[C:21]#[CH:22].[N+:25]([CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)#[C-]>>[CH:27]1([NH:25][C:7]([C:1]2([N:17]([C:20](=[O:24])[C:21]#[CH:22])[C:13]3[CH:14]=[CH:15][CH:16]=[C:11]([C:10]([F:18])([F:19])[F:9])[CH:12]=3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:8])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

5

Reactant 4

HCID 73753-(Trifluoromethyl)anilineHCID 10110Propiolic AcidHCID 16275CyclohexanecarboxaldehydeHCID 79129Cyclohexyl isocyanide

Product 1

HCID 44621464HCID 44621464, compoundYield 28%

Procedure

Cyclohexanecarbaldehyde, 3-trifluoromethylphenylamine, propargylic acid and isocyanocyclohexane were reacted as described in general method E. The compound from Example 26 was obtained in the form of a white solid.

Sources & evidence

ORD record
ord-4921b2d172af4a3395d3b5bc50e7d611
Source dataset
uspto-grants-2013_08
Patent number
US08519188B2

Reaction notes

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