3-(Trifluoromethyl)aniline → HCID 87260834, compound

HRID 1897967Notes

Reaction equation

HRID 1897967 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8].[NH2:13][C:14]1[CH:15]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:18][CH:19]=1>>[CH2:10]([O:9][C:7](=[O:8])[C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[N:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:21])([F:22])[F:23])[CH:15]=1)[CH3:11]

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 77693Ethyl 2-thiopheneglyoxylate

Product 1

HCID 87260834HCID 87260834, compound

Procedure

Intermediate 7 was generated from ethyl thienylglyoxylate and 3-aminobenzo-trifluoride using general method G. The product was then purified on a column of silica gel (heptane/diisopropyl ether) and obtained in the form of a yellow oil.

Workup

  1. customThe product was then purified on a column of silica gel (heptane/diisopropyl ether)
  2. customobtained in the form of a yellow oil

Sources & evidence

ORD record
ord-0c130040b573470795ded45868577318
Source dataset
uspto-grants-2013_08
Patent number
US08519188B2

Reaction notes

Loading…