Trifluoromethyl toluidine → HCID 86762019, compound

HRID 1897969Notes

Reaction equation

HRID 1897969 reaction equation
[N:1]1([C:7](=[O:15])[C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=O)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:16][C:17]1[C:23]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:21]=[CH:20][C:18]=1[NH2:19]>>[CH3:16][C:17]1[C:23]([C:24]([F:25])([F:26])[F:27])=[CH:22][CH:21]=[CH:20][C:18]=1[N:19]=[C:8]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:7]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)=[O:15]

Participants

3

Reactant 2

HCID 2735932Trifluoromethyl toluidineHCID 67079294HCID 67079294, compound

Product 1

HCID 86762019HCID 86762019, compound

Procedure

Intermediate 13 was generated from 1-piperazin-1-yl-2-thiophen-2-yl-ethane-1,2-dione and 2-methyl-3-(trifluoromethyl)aniline using general method L.

Sources & evidence

ORD record
ord-c2da0a635a85404eaf9513c40a3d8147
Source dataset
uspto-grants-2013_08
Patent number
US08519188B2

Reaction notes

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