Morpholine → HCID 57942535, compound

HRID 1898013Notes

Reaction equation

HRID 1898013 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[C:14]([C:19]([OH:21])=O)=[N:15][CH:16]=[CH:17][N:18]=2)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[C:14]([C:19]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[O:21])=[N:15][CH:16]=[CH:17][N:18]=2)(=[O:10])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 57942137HCID 57942137, compound

Product 1

HCID 57942535HCID 57942535, compound

Procedure

This title compound was prepared following procedure described in example 42 step 3 wherein 3-(3,4-dichloro-benzenesulfonylamino)-pyrazine-2-carboxylic acid was coupled with morpholine. The crude was purified by flash column (65% ethyl acetate in hexane) to afford the above title product as a white powder. MS: (M+Na)/z=451.0.

Workup

  1. customThis title compound was prepared following procedure
  2. customThe crude was purified by flash column (65% ethyl acetate in hexane)

Sources & evidence

ORD record
ord-38b420a0f4da4e61b3d3389f28b3f908
Source dataset
uspto-grants-2013_08
Patent number
US08519135B2

Reaction notes

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