HCID 57942346, compound → HCID 57942544, compound

HRID 1898139Notes

Reaction equation

CON(C)[C:4]([C:6]1[C:14]2[N:13]([CH3:15])[C:12](=[O:16])[NH:11][C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:5].Br[C:19]1[C:24]([N:25]([CH2:40][O:41][CH3:42])[S:26]([C:29]2[CH:34]=[CH:33][C:32]([CH3:35])=[C:31]([C:36]([F:39])([F:38])[F:37])[CH:30]=2)(=[O:28])=[O:27])=[CH:23][C:22]([Cl:43])=[CH:21][N:20]=1>>[Cl:43][C:22]1[CH:23]=[C:24]([N:25]([CH2:40][O:41][CH3:42])[S:26]([C:29]2[CH:34]=[CH:33][C:32]([CH3:35])=[C:31]([C:36]([F:38])([F:37])[F:39])[CH:30]=2)(=[O:28])=[O:27])[C:19]([C:4]([C:6]2[C:14]3[N:13]([CH3:15])[C:12](=[O:16])[NH:11][C:10]=3[CH:9]=[CH:8][CH:7]=2)=[O:5])=[N:20][CH:21]=1

Participants

Reactant 2

HCID 57942346HCID 57942346, compound

HCID 57942405HCID 57942405, compound

Product 1

HCID 57942544HCID 57942544, compound

Procedure

N-[5-Chloro-2-(3-methyl-2-oxo-2,3-dihydro-1H-benzoimidazole-4-carbonyl)-pyridin-3-yl]-N-methoxymethyl-4-methyl-3-trifluoromethyl-benzenesulfonamide was prepared from 3-methyl-2-oxo-2,3-dihydro-1H-benzoimidazole-4-carboxylic acid methoxy-methyl-amide and N-(2-bromo-5-chloro-pyridin-3-yl)-N-methoxymethyl-4-methyl-3-trifluoromethyl-benzenesulfonamide according to previously described procedure in example 29, step 1. The product was purified by flash column chromatography on silica gel using ethyl acetate-hexane. MS m/z: 569.0 (M+H)+.

Workup

customThe product was purified by flash column chromatography on silica gel

Sources & evidence

ORD record: ord-6b4f1e5e97c44ce3be64d3ed5e438025
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08519135B2

Reaction notes

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