反应详情

A mixture of N-(2-{[5-chloro-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyridin-2-yl]-hydroxy-methyl}-3-methoxy-phenyl)-2,2-dimethyl-propionamide (0.17 g, 0.33 mmol) and Dess-Martin reagent (0.185 g, 0.44 mmol) in CH2Cl2 (10 mL) at room temperature was stirred for 5 h. A mixture of 10% aqueous Na2S2O3 (10 mL) and saturated aqueous NaHCO3 (10 mL) was then added and the biphasic mixture vigorously stirred for 30 min. The organic phase was then separated and the aqueous portion was extracted with CH2Cl2. The combined organic extracts were washed with saturated aqueous NaHCO3 and brine, dried (Na2SO4), and filtered. The filtrate was concentrated under reduced pressure and the residue purified by chromatography on silica gel using ethyl acetate-hexane to provide N-{2-[5-chloro-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyridine-2-carbonyl]-3-methoxy-phenyl}-2,2-dimethyl-propionamide: MS m/z 604.0 (M+H)+.

1. additionwas then added
2. stirringthe biphasic mixture vigorously stirred for 30 min
3. customThe organic phase was then separated
4. extractionthe aqueous portion was extracted with CH2Cl2
5. washThe combined organic extracts were washed with saturated aqueous NaHCO3 and brine
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. concentrationThe filtrate was concentrated under reduced pressure
9. customthe residue purified by chromatography on silica gel