HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Chloro-3-(propan-2-yl)benzene-1-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfur Dioxide | HCID 1119 | — |
| Reactant | 4-Chloro-3-isopropylaniline | HCID 19891495 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chloro-3-(propan-2-yl)benzene-1-sulfonyl chloride | HCID 58268238 | — |
Reaction Steps
Amounts used: 25 mL of acetic acid was saturated with sulfur dioxide, 671 mg of copper(I) chloride, 4.60 g (27.1 mmol) of 4-chloro-3-isopropyl-phenylamine dissolved in a mixture of 4 mL of acetic acid and 9 mL of concentrated hydrochloric acid, 2.3 g of sodium nitrite in 10 mL of water. Flash chromatography on silica using 3-20% ethyl acetate in hexanes afforded 2.18 g of the product as a white solid. LC-MSD spectrum not observed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519135B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-940a65fb470b40a88ecb9a33a29eb5b5 |
| Source note | uspto-grants-2013_08 |