HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Ethyl-3-trifluoromethyl-benzenesulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfur Dioxide | HCID 1119 | — |
| Reactant | 4-Ethyl-3-(trifluoromethyl)aniline | HCID 21533709 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Ethyl-3-trifluoromethyl-benzenesulfonyl chloride | HCID 58268099 | — |
Reaction Steps
Amounts used: 8 mL of acetic acid was saturated with sulfur dioxide, 190 mg of copper(I) chloride, 1.45 g (7.67 mmol) of 4-ethyl-3-trifluoromethyl-phenylamine dissolved in a mixture of 3 mL of acetic acid and 3 mL of concentrated hydrochloric acid, 0.635 g of sodium nitrite in 3 mL of water. Flash chromatography on silica using 0-20% ethyl acetate in hexanes afforded 0.9 g of the product as a white solid. LC-MSD spectrum not observed; HPLC retention time: 2.9 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519135B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-3cf4d87f48304299a5c29dd319068b8d |
| Source note | uspto-grants-2013_08 |