3-Amino-2-bromo-5-chloropyridine → N-(2-Bromo-5-chloro-pyridin-3-yl)-4-ethyl-3-trifluoromethyl-benzenesulfonamide

HRID 1898242Notes

Reaction equation

HRID 1898242 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][C:4]=1[C:13]([F:16])([F:15])[F:14])[CH3:2].[Br:17][C:18]1[C:23]([NH2:24])=[CH:22][C:21]([Cl:25])=[CH:20][N:19]=1>N1C=CC=CC=1>[Br:17][C:18]1[C:23]([NH:24][S:9]([C:6]2[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:5]=2)(=[O:11])=[O:10])=[CH:22][C:21]([Cl:25])=[CH:20][N:19]=1

Participants

4

Reactant 2

HCID 27696403-Amino-2-bromo-5-chloropyridineHCID 582680994-Ethyl-3-trifluoromethyl-benzenesulfonyl chloride

Product 1

HCID 58268075N-(2-Bromo-5-chloro-pyridin-3-yl)-4-ethyl-3-trifluoromethyl-benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared from 1.04 g (3.82 mmol) of 4-ethyl-3-trifluoromethyl-benzenesulfonyl chloride and 0.87 g (4.20 mmol) of 2-bromo-5-chloro-pyridin-3-ylamine in 3 mL pyridine using procedure x. Yield: 0.45 g of a white solid. LC-MSD, m/z for C14H11BrClF3N2O2S [M+H]+=442.9, 444.9, 446.9

Sources & evidence

ORD record
ord-7c1bf124a69f4084a3c253dd6831ef0e
Source dataset
uspto-grants-2013_08
Patent number
US08519135B2

Reaction notes

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