Chloromethyl Methyl Ether → N-(2-Bromo-5-chloro-pyridin-3-yl)-4-chloro-3-(1-hydroxy-1-methyl-ethyl)-N-methoxymethyl-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Chloromethyl Methyl Ether	HCID 7864	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	N-(2-Bromo-5-chloro-pyridin-3-yl)-4-chloro-3-(1-hydroxy-1-methyl-ethyl)-benzenesulfonamide	HCID 58268046	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	N-(2-Bromo-5-chloro-pyridin-3-yl)-4-chloro-3-(1-hydroxy-1-methyl-ethyl)-N-methoxymethyl-benzenesulfonamide	HCID 58268307	—

Reaction Steps

Prepared from 285 mg (0.648 mmol) of N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro-3-(1-hydroxy-1-methyl-ethyl)-benzenesulfonamide, 268 mg of potassium carbonate and 150 μL of methoxymethyl chloride in 2 mL THF using procedure x. Yield: 153 mg of a white solid. LC-MSD, m/z for C16H17BrCl2N2O4S [M+H]+=482.9, 484.9, 486.9

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08519135B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-d371a8f95fe440df979d1837ae58f5d9
Source note	uspto-grants-2013_08