HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 7-Iodo-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazo[4,5-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| Reactant | HCID 178506554 | HCID 178506554 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Iodo-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazo[4,5-b]pyridine | HCID 57870826 | — |
Reaction Steps
850 mg (3.47 mmol) of 7-iodo-3H-imidazo[4,5-b]pyridine was dissolved in 3.5 mL DMF. 153 mg (3.82 mmol) of 60% sodium hydride was added followed by 670 μL (3.82 mmol) of trimethylsilylethoxymethyl chloride. Yield: 424 mg of an oily product, 90% pure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519135B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-631e413e28b24e18b9ee7aaacbc6cba4 |
| Source note | uspto-grants-2013_08 |