Methanol → 4-Chloro-N-[5-chloro-2-(1H-pyrrolo[2,3-b]pyridine-4-carbonyl)-pyridin-3-yl]-3-isopropyl-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	4-Chloro-3-(propan-2-yl)benzene-1-sulfonyl chloride	HCID 58268238	—
Reactant	(3-Amino-5-chloro-pyridin-2-yl)-(1H-pyrrolo[2,3-b]pyridin-4-yl)-methanone	HCID 58268254	—
Solvent	Water	HCID 962	—
Solvent	Pyridine	HCID 1049	—
Product	4-Chloro-N-[5-chloro-2-(1H-pyrrolo[2,3-b]pyridine-4-carbonyl)-pyridin-3-yl]-3-isopropyl-benzenesulfonamide	HCID 44176831	—

Reaction Steps

Prepared from 25 mg (0.092 mmol) of (3-amino-5-chloro-pyridin-2-yl)-(1H-pyrrolo[2,3-b]pyridin-4-yl)-methanone and 81 mg (0.32 mmol) of 4-chloro-3-iso-propyl-benzenesulfonyl chloride in 0.2 mL pyridine using procedure x. After the sulfonylation was complete, 3 mL methanol, 0.5 mL water and 44 mg sodium hydroxide were used. Yield: 18 mg of a yellow solid. LC-MSD, m/z for C22H18Cl2N4O3S [M+H]+=489.0, 491.0

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08519135B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-de163bc5cd154357bac6fe56107597c0
Source note	uspto-grants-2013_08