HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → 2-Chloro-4-fluoro-1-isothiocyanatobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | Benzenamine, 2-chloro-4-fluoro- | HCID 75013 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Product | 2-Chloro-4-fluoro-1-isothiocyanatobenzene | HCID 2757581 | 46.6% |
Reaction Steps
The title compound was prepared following the procedure described for intermediate-2 using 2-chloro-4-fluoro aniline (5.0 g, 34.48 mmol), thiophosgene (3.95 g, 34.34 mmol), N-ethyl di-isopropyl amine (8.80 g, 68.00 mmol) to afford 3.0 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519149B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-73ee302f906f4566aceadc7713bfbc74 |
| Source note | uspto-grants-2013_08 |