HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → 2-Chloro-4-methylphenyl isothiocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 2-Chloro-p-toluidine | HCID 12007 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Product | 2-Chloro-4-methylphenyl isothiocyanate | HCID 143529 | 58.3% |
Reaction Steps
The title compound was prepared following the procedure described for intermediate-2 using 2-chloro-4-methyl aniline (2.0 g, 14.00 mmol), thiophosgene (1.62 g, 14.00 mmol) and N-ethyl di-isopropyl amine (3.63 g, 28.00 mmol) to afford 1.5 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519149B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-3b59b75f740b42dfa65e357b2132c9af |
| Source note | uspto-grants-2013_08 |