Pyrrolidine → 5-Nitro-2-(1-pyrrolidinyl)pyridine

Participants

Reaction Steps

To a solution of 2-chloro-5-nitropyridine (5.0 g, 0.0315 mol) in ethanol, pyrrolidine (5.5 g, 0.094 mol) was added. The reaction mixture was refluxed for 4-5 h. Ethanol was removed under vacuum and was diluted with water. The reaction mixture was extracted with ethyl acetate and concentrated to afford 5.0 g of the desired product. 1HNMR (CDCl3): δ 2.09 (s, 4H), 3.47-3.71 (m, 4H), 6.34 (d, J=6.3 Hz, 1H), 8.18 (dd, J=1.8 Hz, 1.8 Hz, 1H), 9.05 (s, 1H); MS [M+H]+: 194.30

Provenance & Evidence