2-Chloro-6-Methylphenyl Isothiocyanate → HCID 178496983, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Step-1 of Intermediate-3 using methyl 4,5-diamino-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxylate (Intermediate-1, 0.600 g, 2.54 mmol), acetonitrile (10.0 mL), 1-chloro-2-isothiocyanato-3-methylbenzene (Intermediate-34, 0.500 g, 2.73 mmol) and N,N-di-isopropyl carbodimide (0.300 g) to afford 0.500 g of the desired product. 1HNMR (DMSO-d6): δ 1.42 (s, 6H), 2.23 (s, 3H), 2.98 (s, 2H), 3.71 (s, 3H), 7.02 (d, J=7.5 Hz, 1H), 7.23-7.41 (m, 3H), 9.00 (s, 1H), 10.82 (s, 1H); MS [M+H]+: 386.32.

Provenance & Evidence