Nitric Acid → 4-Fluoro-3-nitrobenzaldehyde

Participants

Reaction Conditions

Reaction Steps

To a cold solution of 4-fluorobenzaldehyde (1 g) in conc. H2SO4 was added conc. HNO3 drop-wise at 0° C. The reaction mass was stirred at 0° C. for 1 h. The reaction mass was quenched in water and filtered to afford 1.2 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 7.82 (t, J=9.3 Hz, 1H), 8.32 (m, 1H), 8.68 (d, J=7.2 Hz, 1H), 10.06 (s, 1H); MS [M+H]+: 184.08.

Provenance & Evidence