HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → 2-Chloro-3-isothiocyanato-4-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Amino-2-chloro-4-methylpyridine | HCID 2756387 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-3-isothiocyanato-4-methylpyridine | HCID 86664691 | 17.4% |
Reaction Steps
The title compound was prepared following the procedure described for Intermediate-2 using 2-chloro-4-methylpyridin-3-amine (4.0 g, 28 mmol), thiophosgene (3.2 g, 28 mmol), N-ethyl di-isopropyl amine (5 mL) in DCM (20 mL) to afford 0.900 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519149B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-f4230426f02d442d95b07d4d8e453b55 |
| Source note | uspto-grants-2013_08 |