Sodium Hydroxide → 2-((2-chloro-6-fluorophenyl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylic Acid

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Reaction Steps

The title compound was prepared following the procedure described for Step-2 of Intermediate-3 using methyl 2-((2-chloro-6-fluorophenyl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (1.0 g, 2.47 mmol), Aq. NaOH (2.0 g, 50.0 mmol) and methanol (2.0 mL) to afford 0.9 g of desired product. 1HNMR (DMSO-d6): δ 1.46 (s, 6H), 3.34 (s, 2H), 3.53 (s, 3H), 6.99 (m, 1H), 7.06 (s, 1H), 7.18 (m, 1H), 7.27 (m, 1H), 10.36 (bs, 1H), 12.08 (bs, 1H).

Provenance & Evidence