Acetic Acid → HCID 178496996, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for step-4 of Intermediate-55 using methyl 2-[(2-chloro-6-fluorophenyl)amino]-6-hydroxy-7-nitro-1H-benzimidazole-5-carboxylate (0.320 g, 0.840 mmol), benzene (6 mL), indium (0.386 g, 3.363 mmol), acetic acid (0.505 g, 8.40 mmol) and trimethyl orthoacetate (0.812 g, 2.96 mmol) to afford 0.195 g of the desired product. 1HNMR (DMSO-d6): δ 2.63 (s, 3H), 3.88 (s, 3H), 7.439-7.46 (m, 3H), 7.71 (s, 1H), 9.0-10.0 (s, 1H), 11.60 (s, 1H); MS [M+H]+: 375.34.

Provenance & Evidence