Sodium Hydroxide → HCID 178524059, compound

HRID 1898351Notes

Reaction equation

HRID 1898351 reaction equation
[CH:1]1([C:4]2[O:5][C:6]3[C:12]([C:13]([O:15]C)=[O:14])=[CH:11][C:10]4[N:17]=[C:18]([NH:20][C:21]5[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=5[Cl:28])[NH:19][C:9]=4[C:7]=3[N:8]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([C:4]2[O:5][C:6]3[C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]4[N:17]=[C:18]([NH:20][C:21]5[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=5[Cl:28])[NH:19][C:9]=4[C:7]=3[N:8]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178496986HCID 178496986, compound

Product 1

HCID 178524059HCID 178524059, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared following the procedure described for Step-5 of Intermediate-55 using methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate (0.100 g, 0.234 mmol), MeOH (3.0 mL) and sodium hydroxide (0.047 g, 1.17 mmol) to afford 0.075 g of the desired product. 1HNMR (DMSO-d6): δ 1.07 (s, 4H), 2.32 (s, 1H), 6.56 (m, 1H), 7.07 (m, 1H), 7.31 (s, 1H), 7.57 (s, 1H), 12.15 (s, 2H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-f58b7d415f7b4280888d28a5fbadfa2e
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

Loading…